Premarin tablets are used as hormone replacement therapy (HRT). This medication manages symptoms of the menopause. Premarin contains conjugated oestrogens, which emulate the female sex hormone oestrogen.

About Premarin Tablets

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premarin cream are used as hormone replacement therapy (HRT). This medication manages symptoms of the menopause. Premarin contains conjugated oestrogens, which emulate the female sex hormone oestrogen. During the menopause, the production of oestrogen in a woman’s ovaries gradually stops. This deficiency can lead to a number of symptoms, including hot flushes, depression, sleep problems, dryness and osteoporosis. For severe symptoms, you may be prescribed Premarin in order to supplement the body’s oestrogen levels. Premarin tablets are available in different strengths such as 0.625mg & 1.25mg

What is Premarin?

Premarin is a female hormone that is used for the treatment of symptoms related to menopause such as hot flashes and vaginal dryness. Apart from treating these symptoms, Premarin may be indicated in the treatment of osteoporosis in women after menopause. It is also used to treat cancers such as breast cancer or prostate cancer in women and men. It can also be used to replace oestrogen in women who cannot produce enough oestrogen due to hypogonadism.

How Does Premarin Work?

When women reach menopause, the ovaries produce less oestrogen, which causes the symptoms of menopause. The conjugated oestrogens in Premarin act as oestrogen replacement hormones that can manage menopausal symptoms such as spotting, chills, sweating and hot flashes. Oestrogen deficiency may also cause osteoporosis in women, which can be treated by Premarin as well.

What Are the Benefits of Taking Premarin?

Premarin is made up of conjugated oestrogens, which is a mixture of oestrogens also known as oestrogen replacement therapy. Oestrogen is a female sex hormone that is produced by the ovaries and used by many processes in the body.

Premarin has the following benefits:

  • Manages symptoms of menopause
  • Treats osteoporosis caused by oestrogen deficiency
  • May treat certain types of cancer in men and women
  • Replaces natural oestrogen when the body is not able to produce it due to any reason

How Do I Use Premarin?

Premarin is an oral tablet that is to be taken by the mouth without chewing, crushing or dissolving the tablet. The medicine can be taken with or after a meal to reduce the chances of an upset stomach.

Premarin should be taken regularly as directed by your doctor for maximum benefit. Take it at the same time every day and follow the correct dosing schedule given by your doctor.

Premarin Dosage

Premarin may be taken daily or for certain conditions your doctor may prescribe Premarin in a cycle. The dosage should be kept according to your doctor’s prescription.

If you miss a dose, you can take it as soon as you remember it. However, if it is almost time for the next dose, you should skip it. Do not take a double dose to make up for the dose that you have missed.

Premarin Precautions and Side Effects

Side Effects

Premarin has certain side effects on some individuals. These side effects may not occur at all or may be non-serious in most cases.

Some common side effects of Premarin include:

  • Nausea, stomach pain or gas
  • Headache
  • Back pain
  • Depression
  • Insomnia
  • Breast pain; or
  • Vaginal itching or discharge
  • Changes in menstrual periods
  • Breakthrough bleeding.

If these side effects persist or worsen, contact your doctor right away.

Premarin also has some other side effects that are rare but quite serious and may require immediate medical attention. These include:

  • Heart attack symptoms
  • Signs of a stroke
  • Signs of a blood clot
  • Swollen or tender stomach
  • Jaundice
  • Disorientation, memory problems, confusion
  • Spotting or pelvic pain
  • A lump in your breast
  • High levels of calcium in your blood

Since every individual reacts to medicines differently, this is not a complete list of all possible side effects. If you notice other side effects not mentioned above, get medical attention and contact your pharmacist or physician for more information.


Before taking Premarin, you should:

  • Discuss your extensive medical history with your doctor especially if you belong to any of the high-risk groups mentioned below.
  • Inform your doctor if you are pregnant, planning for a baby or currently breast-feeding an infant.
  • Be informed that using this medicine may increase risk of blood clots, heart attacks and strokes especially if you have diabetes, high BP, high cholesterol or if you are overweight. premarin vs estradiol


While taking Premarin you should follow some precautions such as:

  • Inform your doctor or dentist about your Premarin intake before a surgical procedure.
  • Tell your doctor if you will be confined to a chair or bed for a long time as it may increase risks of blood clots while on this medicine.
  • Avoid using tobacco or smoking as they can increase your risk of high BO, Heart attack, stroke or blood clots especially if you are older than 35.
  • Wear protective clothes and sunscreen while in sun and limit your sun exposure as Premarin may cause melasma on your face of skin that is worsened by sun exposure.
  • Tell your doctor if you become pregnant or want to breastfeed while on Premarin as it passes into breast milk and should not be taken by pregnant women.
  • Premarin may cause vision problems in people who wear contact lenses, or are near sighted. Contact your doctor if you face any such problems.
  • Avoid consuming grapefruit or grapefruit juice. Conjugated oestrogens may interact with grapefruit or grapefruit juice to show unwanted side effects.

High-Risk Groups

High-risk groups for Premarin include:

  • People who have had a hysterectomy
  • Individuals with heart disease
  • People with liver problems, kidney diseases or gallbladder disease
  • Asthma patients
  • People with epilepsy or other seizure disorders
  • Individuals who suffer from migraines
  • People with Lupus
  • Women with endometriosis or uterine fibroid tumours
  • People with hereditary angioedema
  • Individuals who suffer from porphyria
  • People who have a thyroid disorder
  • People with high levels of calcium in their blood.

Premarin Indications

Premarin is indicated in the treatment of:

  • Abnormal Uterine Bleeding or spotting
  • Atrophic Vaginitis
  • Hypoestrogenism
  • Osteoporosis
  • Postmenopausal Symptoms
  • Primary Ovarian Failure
  • Prostate Cancer or breast cancer

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